{"entity":{"id":"nek10","kind":"target","name":"NEK10","aka":["NIMA related kinase 10","Serine/threonine-protein kinase Nek10","FLJ32685"],"tldr":"NEK10 (Serine/threonine-protein kinase Nek10) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signalling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.37, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18592","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18592"},{"label":"UniProt Q6ZWH5","url":"https://www.uniprot.org/uniprotkb/Q6ZWH5/entry"},{"label":"NCBI Gene 152110","url":"https://www.ncbi.nlm.nih.gov/gene/152110"},{"label":"Ensembl ENSG00000163491","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163491"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NEK10","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18592","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18592","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6ZWH5","url":"https://www.uniprot.org/uniprotkb/Q6ZWH5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000163491","url":"https://platform.opentargets.org/target/ENSG00000163491/associations","note":"association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:18592","ensembl":"ENSG00000163491","uniprot":"Q6ZWH5","entrez":"152110","biology":"Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signalling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport. Locus 3p24.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/nek10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}