{"entity":{"id":"neogb","kind":"trial","name":"NEOGB","aka":[],"tldr":"NEOGB is an Indian phase 3 trial testing whether chemotherapy before surgery improves three-year survival in gallbladder cancer that is still removable but locally advanced. It opened in January 2025 and plans 114 patients.","summary":"NEOGB (NCT06712420) randomises patients with locally advanced but resectable gallbladder carcinoma to neoadjuvant chemotherapy followed by curative surgery or to upfront surgery. Eligibility includes post-cholecystectomy gallbladder cancer with residual disease on imaging, a history of bile spillage or piecemeal removal during the index cholecystectomy, and regional lymph node involvement on imaging. The primary endpoint is improvement in three-year overall survival; 114 patients are planned at three Indian sites, recruitment began in January 2025 and primary completion is listed for April 2028. It complements POLCAGB (unresectable locally advanced disease) and OPT-IN (incidental T2 to T3 disease) as the third randomised test of neoadjuvant treatment in gallbladder cancer.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06712420","url":"https://clinicaltrials.gov/study/NCT06712420"}],"tags":[],"related":[],"cancers":["gallbladder","incidental-gallbladder-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","gallbladder-cancer-surgery"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["radical-cholecystectomy","hepatectomy"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06712420","phase":"3","setting":"Locally advanced resectable gallbladder cancer (including residual disease after cholecystectomy, bile spillage, piecemeal removal or regional node involvement on imaging): neoadjuvant chemotherapy then surgery versus upfront surgery","sponsor":"Rajiv Gandhi Cancer Institute and Research Centre, India","enrolled":114,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/neogb/","neighbours":{"cancer":[{"id":"gallbladder","kind":"cancer","name":"Gallbladder cancer","route":"/cancers/gallbladder/"},{"id":"incidental-gallbladder-cancer","kind":"cancer","name":"Incidental gallbladder cancer (found after cholecystectomy)","route":"/cancers/incidental-gallbladder-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"gallbladder-cancer-surgery","kind":"technology","name":"Surgery for gallbladder cancer: simple versus radical cholecystectomy, re-resection and lymphadenectomy","route":"/technologies/gallbladder-cancer-surgery/"}],"term":[{"id":"gallbladder-cancer-in-biliary-trials","kind":"term","name":"Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups)","route":"/terms/gallbladder-cancer-in-biliary-trials/"},{"id":"hepatectomy","kind":"term","name":"Hepatectomy (liver resection)","route":"/terms/hepatectomy/"},{"id":"radical-cholecystectomy","kind":"term","name":"Radical (extended) cholecystectomy","route":"/terms/radical-cholecystectomy/"}]}}