{"entity":{"id":"nfib","kind":"target","name":"NFIB","aka":["nuclear factor I B","Nuclear factor 1 B-type","NFI-RED","NFIB2","NFIB3"],"tldr":"NFIB (Nuclear factor 1 B-type) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Oral cavity cancer and Adenoid cystic carcinoma.","summary":"Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.31, literature 0.98, genetic association 0.35, somatic mutation 0.94, animal model 0.85).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7785","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7785"},{"label":"UniProt O00712","url":"https://www.uniprot.org/uniprotkb/O00712/entry"},{"label":"NCBI Gene 4781","url":"https://www.ncbi.nlm.nih.gov/gene/4781"},{"label":"Ensembl ENSG00000147862","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147862"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","oral-cavity-cancer","adenoid-cystic-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NFIB","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7785","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7785","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O00712","url":"https://www.uniprot.org/uniprotkb/O00712/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000147862","url":"https://platform.opentargets.org/target/ENSG00000147862/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: breast cancer 0.52, oral cavity cancer 0.55, adenoid cystic carcinoma 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:7785","ensembl":"ENSG00000147862","uniprot":"O00712","entrez":"4781","biology":"Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Location: Nucleus (UniProt). Locus 9p23-p22.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)","Oral cavity cancer: Open Targets association 0.55 with oral cavity cancer (MONDO_0005515)","Adenoid cystic carcinoma: Open Targets association 0.52 with adenoid cystic carcinoma (MONDO_0004971)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/nfib/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"adenoid-cystic-carcinoma","kind":"cancer","name":"Adenoid cystic carcinoma","route":"/cancers/adenoid-cystic-carcinoma/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"}]}}