{"entity":{"id":"nfkbie","kind":"target","name":"NFKBIE","aka":["NFKB inhibitor epsilon","NF-kappa-B inhibitor epsilon"],"tldr":"NFKBIE (NF-kappa-B inhibitor epsilon) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Skin cancer and 5 more.","summary":"Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity. Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes. Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.72, genetic association 0.00, somatic mutation 0.81). IntOGen calls it a driver in 7 cohorts (3 activating, 4 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Diffuse Large B-Cell Lymphoma, NOS, Lung Adenocarcinoma, Malignant Lymphoma, Non-Hodgkin Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7799","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7799"},{"label":"UniProt O00221","url":"https://www.uniprot.org/uniprotkb/O00221/entry"},{"label":"NCBI Gene 4794","url":"https://www.ncbi.nlm.nih.gov/gene/4794"},{"label":"Ensembl ENSG00000146232","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000146232"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["non-hodgkin-lymphoma","leukaemia","skin-cancer","dlbcl","mantle-cell-lymphoma","cll","nsclc","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NFKBIE","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7799","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7799","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O00221","url":"https://www.uniprot.org/uniprotkb/O00221/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NFKBIE","url":"https://civicdb.org/features/3887","note":"2 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma, Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000146232","url":"https://platform.opentargets.org/target/ENSG00000146232/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: melanoma 0.55, acute lymphoblastic leukaemia 0.54, diffuse large B-cell lymphoma 0.53, non-Hodgkin lymphoma 0.68, skin cancer 0.56, leukaemia 0.62 (GraphQL API, CC0)"},{"label":"IntOGen NFKBIE","url":"https://www.intogen.org/search?gene=NFKBIE","note":"driver in 7 cohorts (Act 3, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:7799","ensembl":"ENSG00000146232","uniprot":"O00221","entrez":"4794","biology":"Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity. Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes. Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development. Location: Cytoplasm (UniProt). Locus 6p21.1 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.68 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 2 cohorts (MLYM, NHL)","Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Diffuse large B-cell lymphoma: Open Targets association 0.53 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease","Mantle cell lymphoma: CIViC evidence names this disease","Chronic lymphocytic leukaemia: IntOGen driver in 2 cohorts (CLLSLL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/nfkbie/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"mantle-cell-lymphoma","kind":"cancer","name":"Mantle cell lymphoma","route":"/cancers/mantle-cell-lymphoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}