{"entity":{"id":"nkt3964","kind":"drug","name":"NKT3964","aka":[],"tldr":"NKT3964 is an experimental protein degrader from NiKang Therapeutics, in phase 1 trials for CCNE1-amplified endometrial and ovarian cancer.","summary":"NKT3964 is a small molecule PROTAC degrader, oral from NiKang Therapeutics. A selective degrader of CDK2, a cell-cycle enzyme that cancers with extra copies of the CCNE1 gene rely on. The phase 1 study NCT06586957 is recruiting; the company says it is now enrolling people with CCNE1-amplified endometrial cancer. Whether it works in people has not been established.","status":"phase-1","asOf":"2026-11-04","links":[{"label":"NiKang science and pipeline","url":"https://www.nikangtx.com/science-and-pipeline/"},{"label":"ClinicalTrials.gov NCT06586957","url":"https://clinicaltrials.gov/study/NCT06586957"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["endometrial","ovarian"],"sections":[],"technologies":[],"targets":["cdk2"],"drugs":[],"companies":["nikang-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06586957"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors, investor portfolios (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-04"},"code":"NKT3964","modality":"Small molecule PROTAC degrader, oral","mechanism":"A selective degrader of CDK2, a cell-cycle enzyme that cancers with extra copies of the CCNE1 gene rely on.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/nkt3964/","neighbours":{"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"target":[{"id":"cdk2","kind":"target","name":"CDK2","route":"/targets/cdk2/"}],"company":[{"id":"nikang-therapeutics","kind":"company","name":"NiKang Therapeutics","route":"/companies/nikang-therapeutics/"}],"trial":[{"id":"nct06586957","kind":"trial","name":"A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors","route":"/trials/nct06586957/"}]}}