{"entity":{"id":"nktr","kind":"target","name":"NKTR","aka":["natural killer cell triggering receptor","NK-tumor recognition protein","p104","CypNK"],"tldr":"NKTR (NK-tumour recognition protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.","summary":"PPIase that catalyses the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumour-recognition complex involved in the function of NK cells.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7833","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7833"},{"label":"UniProt P30414","url":"https://www.uniprot.org/uniprotkb/P30414/entry"},{"label":"NCBI Gene 4820","url":"https://www.ncbi.nlm.nih.gov/gene/4820"},{"label":"Ensembl ENSG00000114857","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114857"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct03635983","nct03729245"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NKTR","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:7833","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7833","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P30414","url":"https://www.uniprot.org/uniprotkb/P30414/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen NKTR","url":"https://www.intogen.org/search?gene=NKTR","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:7833","ensembl":"ENSG00000114857","uniprot":"P30414","entrez":"4820","biology":"PPIase that catalyses the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumour-recognition complex involved in the function of NK cells. Location: Cell membrane (UniProt). Locus 3p22.1 (HGNC).","whereFound":["Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/nktr/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}],"trial":[{"id":"nct03729245","kind":"trial","name":"A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)","route":"/trials/nct03729245/"},{"id":"nct03635983","kind":"trial","name":"A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma","route":"/trials/nct03635983/"}]}}