{"entity":{"id":"nngm","kind":"institution","name":"nationales Netzwerk Genomische Medizin Lungenkrebs","aka":["nNGM","Network Genomic Medicine","NGM Cologne"],"tldr":"The German network that gets comprehensive molecular testing to lung cancer patients anywhere in the country, paid for by selective contracts with 66 sickness funds rather than by waiting for the national benefits catalogue.","summary":"The nationale Netzwerk Genomische Medizin Lungenkrebs grew out of the Cologne Network Genomic Medicine, which from 2012 ran comprehensive molecular pathology for referring hospitals on a single diagnostic platform at University Hospital Cologne under Jürgen Wolf and Reinhard Büttner. Deutsche Krebshilfe rolled the model out nationally with one of its largest single grants from 1 April 2018. The network lists 29 centres and more than 500 partner hospitals and specialist practices, and reports on the actionable alterations in non-small-cell lung cancer: KRAS, EGFR, ALK, BRAF, MET, RET, ROS1, HER2 and NTRK.\n\nThe financing is the distinctive part. Testing and a second opinion are paid for under selective contracts for besondere Versorgung under section 140a SGB V, which expressly permit terms departing from the ordinary reimbursement rules; 66 cooperating sickness funds covering 94.79 percent of patients had signed as at June 2025, with contracts dating from 2019. A historical cohort linking the nNGM database to AOK claims found median overall survival of 10.5 months against 8.7 for patients treated outside the network (hazard ratio 0.84) and more first-line use of approved targeted drugs; it was funded by the insurers themselves. Coverage is uneven geographically: 668 German hospitals treating 26 percent of lung cancer cases belong to no network at all.","asOf":"2026-09-25","links":[{"label":"nNGM Lungenkrebs","url":"https://www.nngm.de"},{"label":"Cooperating sickness funds","url":"https://nngm.de/ueber-das-nngm/kooperationskrankenkassen/"},{"label":"Kästner 2024, outcomes (Lancet Reg Health Eur)","url":"https://doi.org/10.1016/j.lanepe.2023.100788"},{"label":"Büttner 2019, the Cologne model (Der Pathologe)","url":"https://doi.org/10.1007/s00292-019-0605-4"}],"tags":[],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["ngs","genomic-profiling"],"targets":["egfr","alk","kras","met","ret","ros1"],"drugs":[],"companies":[],"institutions":["uniklinik-koeln","deutsche-krebshilfe","dkfz","lungenclinic-grosshansdorf","charite"],"pathways":[],"terms":[],"trials":[],"people":["juergen-wolf","reinhard-buettner","martin-reck"],"bottlenecks":["b-biomarker-validation","b-data-silos"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Cologne","country":"DE","lat":50.938,"lng":6.96,"institutionType":"consortium","website":"https://www.nngm.de","programs":["Comprehensive molecular diagnostics for NSCLC","Second opinion consultations at network centres","Selective contracts under section 140a SGB V","nNGM registry (NCT05934032)"]},"route":"/institutions/nngm/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"term":[{"id":"genomic-profiling","kind":"term","name":"Genomic profiling","route":"/terms/genomic-profiling/"},{"id":"ngs","kind":"term","name":"Next-generation sequencing (NGS)","route":"/terms/ngs/"}],"target":[{"id":"alk","kind":"target","name":"ALK","route":"/targets/alk/"},{"id":"egfr","kind":"target","name":"EGFR","route":"/targets/egfr/"},{"id":"kras","kind":"target","name":"KRAS","route":"/targets/kras/"},{"id":"met","kind":"target","name":"MET","route":"/targets/met/"},{"id":"ret","kind":"target","name":"RET","route":"/targets/ret/"},{"id":"ros1","kind":"target","name":"ROS1","route":"/targets/ros1/"}],"institution":[{"id":"charite","kind":"institution","name":"Charité Universitätsmedizin Berlin","route":"/institutions/charite/"},{"id":"deutsche-krebshilfe","kind":"institution","name":"Deutsche Krebshilfe","route":"/institutions/deutsche-krebshilfe/"},{"id":"dnpm","kind":"institution","name":"Deutsches Netzwerk für Personalisierte Medizin","route":"/institutions/dnpm/"},{"id":"dkfz","kind":"institution","name":"German Cancer Research Center (DKFZ)","route":"/institutions/dkfz/"},{"id":"lungenclinic-grosshansdorf","kind":"institution","name":"LungenClinic Grosshansdorf","route":"/institutions/lungenclinic-grosshansdorf/"},{"id":"uniklinik-koeln","kind":"institution","name":"Uniklinik Köln (CIO)","route":"/institutions/uniklinik-koeln/"}],"person":[{"id":"juergen-wolf","kind":"person","name":"Jürgen Wolf","route":"/people/juergen-wolf/"},{"id":"martin-reck","kind":"person","name":"Martin Reck","route":"/people/martin-reck/"},{"id":"reinhard-buettner","kind":"person","name":"Reinhard Büttner","route":"/people/reinhard-buettner/"}],"bottleneck":[{"id":"b-biomarker-validation","kind":"bottleneck","name":"Biomarkers are not validated or standardised","route":"/bottlenecks/b-biomarker-validation/"},{"id":"b-data-silos","kind":"bottleneck","name":"Data silos","route":"/bottlenecks/b-data-silos/"}]}}