{"entity":{"id":"nptxr","kind":"target","name":"NPTXR","aka":["neuronal pentraxin receptor","Neuronal pentraxin receptor"],"tldr":"NPTXR (Neuronal pentraxin receptor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.","summary":"May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin and Fluorouracil.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7954","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7954"},{"label":"UniProt O95502","url":"https://www.uniprot.org/uniprotkb/O95502/entry"},{"label":"NCBI Gene 23467","url":"https://www.ncbi.nlm.nih.gov/gene/23467"},{"label":"Ensembl ENSG00000221890","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000221890"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NPTXR","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7954","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7954","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95502","url":"https://www.uniprot.org/uniprotkb/O95502/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NPTXR","url":"https://civicdb.org/features/9581","note":"1 evidence items, 0 assertions, 1 variants; diseases: Stomach Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:7954","ensembl":"ENSG00000221890","uniprot":"O95502","entrez":"23467","biology":"May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Location: Membrane (UniProt). Locus 22q13.1 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/nptxr/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}