{"entity":{"id":"nr2f2","kind":"target","name":"NR2F2","aka":["nuclear receptor subfamily 2 group F member 2","COUP transcription factor 2","COUP-TFII","COUPTFB","SVP40","NF-E3","COUPTF2","ARP1","TFCOUP2"],"tldr":"NR2F2 (COUP transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7976","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7976"},{"label":"UniProt P24468","url":"https://www.uniprot.org/uniprotkb/P24468/entry"},{"label":"NCBI Gene 7026","url":"https://www.ncbi.nlm.nih.gov/gene/7026"},{"label":"Ensembl ENSG00000185551","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185551"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NR2F2","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7976","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7976","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P24468","url":"https://www.uniprot.org/uniprotkb/P24468/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NR2F2","url":"https://civicdb.org/features/5731","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:7976","ensembl":"ENSG00000185551","uniprot":"P24468","entrez":"7026","biology":"Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development. Location: Nucleus (UniProt). Locus 15q26.2 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/nr2f2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}