{"entity":{"id":"nrg2","kind":"target","name":"NRG2","aka":["neuregulin 2","Pro-neuregulin-2, membrane-bound isoform","Don-1","HRG2"],"tldr":"NRG2 (Pro-neuregulin-2, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerisation with the EGF receptor.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.95, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7998","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7998"},{"label":"UniProt O14511","url":"https://www.uniprot.org/uniprotkb/O14511/entry"},{"label":"NCBI Gene 9542","url":"https://www.ncbi.nlm.nih.gov/gene/9542"},{"label":"Ensembl ENSG00000158458","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158458"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NRG2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7998","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7998","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O14511","url":"https://www.uniprot.org/uniprotkb/O14511/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000158458","url":"https://platform.opentargets.org/target/ENSG00000158458/associations","note":"association with cancer (MONDO_0004992) 0.60;  (GraphQL API, CC0)"}],"hgnc":"HGNC:7998","ensembl":"ENSG00000158458","uniprot":"O14511","entrez":"9542","biology":"Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerisation with the EGF receptor. Location: Cell membrane; Secreted (UniProt). Locus 5q31.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/nrg2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}