{"entity":{"id":"nrk","kind":"target","name":"NRK","aka":["Nik related kinase","Nik-related protein kinase","DKFZp686A17109"],"tldr":"NRK (Nik-related protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.","summary":"May phosphorylate cofilin-1 and induce actin polymerisation through this process, during the late stages of embryogenesis. Involved in the TNF-induced signalling pathway.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25391","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25391"},{"label":"UniProt Q7Z2Y5","url":"https://www.uniprot.org/uniprotkb/Q7Z2Y5/entry"},{"label":"NCBI Gene 203447","url":"https://www.ncbi.nlm.nih.gov/gene/203447"},{"label":"Ensembl ENSG00000123572","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123572"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NRK","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25391","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25391","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z2Y5","url":"https://www.uniprot.org/uniprotkb/Q7Z2Y5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen NRK","url":"https://www.intogen.org/search?gene=NRK","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:25391","ensembl":"ENSG00000123572","uniprot":"Q7Z2Y5","entrez":"203447","biology":"May phosphorylate cofilin-1 and induce actin polymerisation through this process, during the late stages of embryogenesis. Involved in the TNF-induced signalling pathway. Locus Xq22.3 (HGNC).","whereFound":["Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/nrk/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}