{"entity":{"id":"nt5c3a","kind":"target","name":"NT5C3A","aka":["5'-nucleotidase, cytosolic IIIA","Cytosolic 5'-nucleotidase 3A","UMPH1","PSN1","PN-I","P5'N-1","cN-III","p36","hUMP1","NT5C3"],"tldr":"NT5C3A (Cytosolic 5'-nucleotidase 3A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.","summary":"Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17820"},{"label":"UniProt Q9H0P0","url":"https://www.uniprot.org/uniprotkb/Q9H0P0/entry"},{"label":"NCBI Gene 51251","url":"https://www.ncbi.nlm.nih.gov/gene/51251"},{"label":"Ensembl ENSG00000122643","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000122643"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NT5C3A","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:17820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17820","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H0P0","url":"https://www.uniprot.org/uniprotkb/Q9H0P0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen NT5C3A","url":"https://www.intogen.org/search?gene=NT5C3A","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:17820","ensembl":"ENSG00000122643","uniprot":"Q9H0P0","entrez":"51251","biology":"Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. Location: Cytoplasm; Endoplasmic reticulum (UniProt). Locus 7p14.3 (HGNC).","whereFound":["Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/nt5c3a/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}]}}