{"entity":{"id":"nthl1","kind":"target","name":"NTHL1","aka":["nth like DNA glycosylase 1","Endonuclease III-like protein 1","NTH1","OCTS3"],"tldr":"NTHL1 (Endonuclease III-like protein 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.76, affected pathway 0.91, literature 0.93, genetic association 0.61, somatic mutation 0.49, animal model 0.47).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8028","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8028"},{"label":"UniProt P78549","url":"https://www.uniprot.org/uniprotkb/P78549/entry"},{"label":"NCBI Gene 4913","url":"https://www.ncbi.nlm.nih.gov/gene/4913"},{"label":"Ensembl ENSG00000065057","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000065057"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NTHL1","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:8028","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8028","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P78549","url":"https://www.uniprot.org/uniprotkb/P78549/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000065057","url":"https://platform.opentargets.org/target/ENSG00000065057/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0)"}],"hgnc":"HGNC:8028","ensembl":"ENSG00000065057","uniprot":"P78549","entrez":"4913","biology":"Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognises and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Location: Nucleus; Mitochondrion (UniProt). Locus 16p13.3 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/nthl1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}