{"entity":{"id":"nuh-limb-cryocompression-expansion","kind":"trial","name":"Singapore limb cryocompression expansion study","aka":["A Novel Limb Cryocompression System for Prevention of Chemotherapy Induced Peripheral Neuropathy - Expansion Study"],"tldr":"A Singapore study that builds on the earlier safety work with a cooling-and-compression device for the hands and feet, now in 200 patients.","summary":"The National University Hospital, Singapore, group that published a safety series of continuous-flow limb cryocompression (13 patients, 142 cycles, no grade 2 or worse neuropathy) is running an expansion study of the Paxman Limb Cryocompression System with an estimated 200 participants. Its earlier studies are NCT03299582 and NCT05095051.","status":"recruiting","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT05606068","url":"https://clinicaltrials.gov/study/NCT05606068"},{"label":"Bandla et al., safety of continuous-flow limb cryocompression in 13 patients (Support Care Cancer 2020)","url":"https://doi.org/10.1007/s00520-019-05177-2"},{"label":"ClinicalTrials.gov NCT03299582","url":"https://clinicaltrials.gov/study/NCT03299582"},{"label":"ClinicalTrials.gov NCT05095051","url":"https://clinicaltrials.gov/study/NCT05095051"}],"tags":["machines-wave3"],"related":[],"cancers":[],"sections":[],"technologies":["limb-cryocompression-devices"],"targets":[],"drugs":[],"companies":["paxman"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo machines inventory (openFDA, accessdata.fda.gov, ClinicalTrials.gov v2, Europe PMC, maker pages)","editedOn":"2026-11-04"},"nct":"NCT05606068","phase":"not-applicable","setting":"Patients receiving neurotoxic chemotherapy, using the Paxman Limb Cryocompression System","sponsor":"National University Hospital, Singapore","started":"2022-11-11","startedType":"actual","enrolled":200,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nuh-limb-cryocompression-expansion/","neighbours":{"technology":[{"id":"limb-cryocompression-devices","kind":"technology","name":"Limb cryocompression devices for chemotherapy nerve damage (Paxman Neuropathy System, Hilotherm ChemoCare)","route":"/technologies/limb-cryocompression-devices/"}],"company":[{"id":"paxman","kind":"company","name":"Paxman","route":"/companies/paxman/"}]}}