{"entity":{"id":"nup214","kind":"target","name":"NUP214","aka":["nucleoporin 214","Nuclear pore complex protein Nup214","D9S46E","N214"],"tldr":"NUP214 (Nuclear pore complex protein Nup214) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Renal cell carcinoma and 4 more.","summary":"Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.28, somatic mutation 0.76). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Papillary Renal Cell Carcinoma, Small Intestinal Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8064","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8064"},{"label":"UniProt P35658","url":"https://www.uniprot.org/uniprotkb/P35658/entry"},{"label":"NCBI Gene 8021","url":"https://www.ncbi.nlm.nih.gov/gene/8021"},{"label":"Ensembl ENSG00000126883","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126883"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["leukaemia","non-hodgkin-lymphoma","rcc","small-bowel","myeloproliferative-neoplasms","papillary-rcc","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NUP214","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:8064","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8064","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35658","url":"https://www.uniprot.org/uniprotkb/P35658/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000126883","url":"https://platform.opentargets.org/target/ENSG00000126883/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.55, non-Hodgkin lymphoma 0.59, myeloproliferative neoplasm 0.53, leukaemia 0.60 (GraphQL API, CC0)"},{"label":"IntOGen NUP214","url":"https://www.intogen.org/search?gene=NUP214","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8064","ensembl":"ENSG00000126883","uniprot":"P35658","entrez":"8021","biology":"Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. Location: Nucleus, nuclear pore complex (UniProt). Locus 9q34.13 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908)","Renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)","Small intestine cancer: IntOGen driver in 1 cohort (SIC)","Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076)","Papillary renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/nup214/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"papillary-rcc","kind":"cancer","name":"Papillary renal cell carcinoma","route":"/cancers/papillary-rcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"small-bowel","kind":"cancer","name":"Small intestine cancer (small bowel adenocarcinoma)","route":"/cancers/small-bowel/"}]}}