{"entity":{"id":"nup98","kind":"target","name":"NUP98","aka":["nucleoporin 98 and 96 precursor","Nuclear pore complex protein Nup98-Nup96","NUP96","Nup98-Nup96","Nup98-96","NUP196"],"tldr":"NUP98 (Nuclear pore complex protein Nup98-Nup96) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Lung cancer, Leukaemia and 3 more.","summary":"Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Lung Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8068","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8068"},{"label":"UniProt P52948","url":"https://www.uniprot.org/uniprotkb/P52948/entry"},{"label":"NCBI Gene 4928","url":"https://www.ncbi.nlm.nih.gov/gene/4928"},{"label":"Ensembl ENSG00000110713","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110713"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["skin-cancer","lung-cancer","leukaemia","breast-cancer","nsclc","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NUP98","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:8068","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8068","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P52948","url":"https://www.uniprot.org/uniprotkb/P52948/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000110713","url":"https://platform.opentargets.org/target/ENSG00000110713/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: melanoma 0.52, skin cancer 0.55, breast cancer 0.52, lung cancer 0.54, leukaemia 0.54 (GraphQL API, CC0)"},{"label":"IntOGen NUP98","url":"https://www.intogen.org/search?gene=NUP98","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8068","ensembl":"ENSG00000110713","uniprot":"P52948","entrez":"4928","biology":"Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localisation of DHX9 in discrete intranuclear foci (GLFG-body). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro). Location: Nucleus membrane; Nucleus, nuclear pore complex; Nucleus, nucleoplasm (UniProt). Locus 11p15.4 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)","Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)","Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)","Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/nup98/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}