{"entity":{"id":"nutm1","kind":"target","name":"NUTM1","aka":["NUT midline carcinoma family member 1","NUT family member 1","DKFZp434O192","FAM22H","C15orf55"],"tldr":"NUTM1 (NUT family member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Oesophageal cancer, Ovarian cancer and 4 more.","summary":"Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.84, affected pathway 0.61, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Oesophageal Adenocarcinoma, Ovarian Epithelial Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29919","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29919"},{"label":"UniProt Q86Y26","url":"https://www.uniprot.org/uniprotkb/Q86Y26/entry"},{"label":"NCBI Gene 256646","url":"https://www.ncbi.nlm.nih.gov/gene/256646"},{"label":"Ensembl ENSG00000184507","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184507"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["skin-cancer","esophageal","ovarian","lung-cancer","oesophageal-adenocarcinoma","melanoma","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NUTM1","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29919","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29919","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86Y26","url":"https://www.uniprot.org/uniprotkb/Q86Y26/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000184507","url":"https://platform.opentargets.org/target/ENSG00000184507/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.53, melanoma 0.56, skin cancer 0.59, lung cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen NUTM1","url":"https://www.intogen.org/search?gene=NUTM1","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29919","ensembl":"ENSG00000184507","uniprot":"Q86Y26","entrez":"256646","biology":"Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Location: Cytoplasm; Nucleus (UniProt). Locus 15q14 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.59 with skin cancer (MONDO_0002898)","Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)","Ovarian cancer: IntOGen driver in 1 cohort (OVT)","Lung cancer: Open Targets association 0.56 with lung cancer (MONDO_0008903)","Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)","Melanoma: Open Targets association 0.56 with melanoma (MONDO_0005105)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/nutm1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}