{"entity":{"id":"nutm2b","kind":"target","name":"NUTM2B","aka":["NUT family member 2B","bA119F19.1","FAM22B"],"tldr":"NUTM2B (NUT family member 2B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.","summary":"UniProt has no function text for A6NNL0; HGNC names it \"NUT family member 2B\".\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.70, genetic association 0.00, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23445","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23445"},{"label":"UniProt A6NNL0","url":"https://www.uniprot.org/uniprotkb/A6NNL0/entry"},{"label":"NCBI Gene 729262","url":"https://www.ncbi.nlm.nih.gov/gene/729262"},{"label":"Ensembl ENSG00000188199","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000188199"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NUTM2B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23445","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23445","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt A6NNL0","url":"https://www.uniprot.org/uniprotkb/A6NNL0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000188199","url":"https://platform.opentargets.org/target/ENSG00000188199/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: sarcoma 0.58 (GraphQL API, CC0)"}],"hgnc":"HGNC:23445","ensembl":"ENSG00000188199","uniprot":"A6NNL0","entrez":"729262","biology":"UniProt has no function text for A6NNL0; HGNC names it \"NUT family member 2B\". Locus 10q22.3 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.58 with sarcoma (MONDO_0005089)"],"targetClass":"other","prevalence":[]},"route":"/targets/nutm2b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}