{"entity":{"id":"nvl","kind":"target","name":"NVL","aka":["nuclear VCP like","Nuclear valosin-containing protein-like","NVL2"],"tldr":"NVL (Nuclear valosin-containing protein-like) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.","summary":"Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8070","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8070"},{"label":"UniProt O15381","url":"https://www.uniprot.org/uniprotkb/O15381/entry"},{"label":"NCBI Gene 4931","url":"https://www.ncbi.nlm.nih.gov/gene/4931"},{"label":"Ensembl ENSG00000143748","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143748"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct05118789","nct06765109"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NVL","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:8070","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8070","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15381","url":"https://www.uniprot.org/uniprotkb/O15381/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen NVL","url":"https://www.intogen.org/search?gene=NVL","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8070","ensembl":"ENSG00000143748","uniprot":"O15381","entrez":"4931","biology":"Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyses the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. Location: Nucleus, nucleoplasm; Nucleus, nucleolus (UniProt). Locus 1q42.11 (HGNC).","whereFound":["Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/nvl/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"trial":[{"id":"nct05118789","kind":"trial","name":"A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)","route":"/trials/nct05118789/"},{"id":"nct06765109","kind":"trial","name":"Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC","route":"/trials/nct06765109/"}]}}