{"entity":{"id":"nxf1","kind":"target","name":"NXF1","aka":["nuclear RNA export factor 1","Nuclear RNA export factor 1","Mex67","DKFZp667O0311"],"tldr":"NXF1 (Nuclear RNA export factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Chronic lymphocytic leukaemia.","summary":"Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8071","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8071"},{"label":"UniProt Q9UBU9","url":"https://www.uniprot.org/uniprotkb/Q9UBU9/entry"},{"label":"NCBI Gene 10482","url":"https://www.ncbi.nlm.nih.gov/gene/10482"},{"label":"Ensembl ENSG00000162231","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162231"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["cll"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NXF1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:8071","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8071","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UBU9","url":"https://www.uniprot.org/uniprotkb/Q9UBU9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen NXF1","url":"https://www.intogen.org/search?gene=NXF1","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8071","ensembl":"ENSG00000162231","uniprot":"Q9UBU9","entrez":"10482","biology":"Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Location: Nucleus; Nucleus, nucleoplasm; Nucleus speckle; Nucleus, nuclear pore complex (UniProt). Locus 11q12.3 (HGNC).","whereFound":["Chronic lymphocytic leukaemia: IntOGen driver in 2 cohorts (CLLSLL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/nxf1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"}]}}