{"entity":{"id":"oc-lead","kind":"trial","name":"OC-LEAD (Galleri in BRCA carriers at risk of ovarian cancer)","aka":["OC-LEAD"],"tldr":"A feasibility study of the Galleri blood test in people with BRCA gene changes who face a high risk of ovarian cancer.","summary":"OC-LEAD (NCT07764744) is a non-randomised interventional study sponsored by Weill Medical College of Cornell University with M.D. Anderson Cancer Center. Its primary outcomes are the feasibility of Galleri testing in a surgical BRCA1/2 cohort and of annual testing in a cohort with serous tubal intraepithelial carcinoma.\n\nThe registry record, read on 29 October 2026, gives its status as not yet recruiting, with an estimated 70 participants, a planned start in October 2026 and primary completion expected in October 2039.","status":"planned","asOf":"2026-10-29","links":[{"label":"ClinicalTrials.gov NCT07764744","url":"https://clinicaltrials.gov/study/NCT07764744"}],"tags":[],"related":[],"cancers":["ovarian"],"sections":["early-detection"],"technologies":["mced","liquid-biopsy"],"targets":[],"drugs":["galleri"],"companies":["grail"],"institutions":["md-anderson"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07764744","phase":"not-applicable","setting":"People with a BRCA1 or BRCA2 pathogenic variant at high risk of ovarian cancer, including a cohort with serous tubal intraepithelial carcinoma, given the Galleri test","sponsor":"Weill Medical College of Cornell University with M.D. Anderson Cancer Center","started":"2026-10","startedType":"estimated","enrolled":70,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/oc-lead/","neighbours":{"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"drug":[{"id":"galleri","kind":"drug","name":"Galleri","route":"/drugs/galleri/"}],"company":[{"id":"grail","kind":"company","name":"GRAIL","route":"/companies/grail/"}],"institution":[{"id":"md-anderson","kind":"institution","name":"MD Anderson Cancer Center","route":"/institutions/md-anderson/"}]}}