{"entity":{"id":"ogg1","kind":"target","name":"OGG1","aka":["8-oxoguanine DNA glycosylase","N-glycosylase/DNA lyase","HOGG1","OGH1"],"tldr":"OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.","summary":"DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes genetic literature 0.30, affected pathway 0.89, literature 0.98, genetic association 0.01, somatic mutation 0.55, animal model 0.74).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8125","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8125"},{"label":"UniProt O15527","url":"https://www.uniprot.org/uniprotkb/O15527/entry"},{"label":"NCBI Gene 4968","url":"https://www.ncbi.nlm.nih.gov/gene/4968"},{"label":"Ensembl ENSG00000114026","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114026"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"OGG1","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:8125","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8125","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15527","url":"https://www.uniprot.org/uniprotkb/O15527/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000114026","url":"https://platform.opentargets.org/target/ENSG00000114026/associations","note":"association with cancer (MONDO_0004992) 0.66;  (GraphQL API, CC0)"}],"hgnc":"HGNC:8125","ensembl":"ENSG00000114026","uniprot":"O15527","entrez":"4968","biology":"DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Location: Nucleus, nucleoplasm; Nucleus speckle; Nucleus matrix; Nucleus (UniProt). Locus 3p25.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ogg1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}