{"entity":{"id":"olig2","kind":"target","name":"OLIG2","aka":["oligodendrocyte transcription factor 2","Oligodendrocyte transcription factor 2","RACK17","OLIGO2","bHLHe19","PRKCBP2","BHLHB1"],"tldr":"OLIG2 (Oligodendrocyte transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Works in coordination with ZNF488 to promote oligodendrocyte differentiation. Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.95, animal model 0.38, genetic association 0.00, somatic mutation 0.94).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9398","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9398"},{"label":"UniProt Q13516","url":"https://www.uniprot.org/uniprotkb/Q13516/entry"},{"label":"NCBI Gene 10215","url":"https://www.ncbi.nlm.nih.gov/gene/10215"},{"label":"Ensembl ENSG00000205927","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000205927"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"OLIG2","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9398","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9398","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13516","url":"https://www.uniprot.org/uniprotkb/Q13516/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000205927","url":"https://platform.opentargets.org/target/ENSG00000205927/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:9398","ensembl":"ENSG00000205927","uniprot":"Q13516","entrez":"10215","biology":"Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Works in coordination with ZNF488 to promote oligodendrocyte differentiation. Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) generation through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Location: Nucleus; Cytoplasm (UniProt). Locus 21q22.11 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/olig2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}