{"entity":{"id":"orc1","kind":"target","name":"ORC1","aka":["origin recognition complex subunit 1","Origin recognition complex subunit 1","HSORC1","PARC1","ORC1L"],"tldr":"ORC1 (Origin recognition complex subunit 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.","summary":"Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8487","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8487"},{"label":"UniProt Q13415","url":"https://www.uniprot.org/uniprotkb/Q13415/entry"},{"label":"NCBI Gene 4998","url":"https://www.ncbi.nlm.nih.gov/gene/4998"},{"label":"Ensembl ENSG00000085840","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085840"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["tnbc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ORC1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:8487","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8487","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13415","url":"https://www.uniprot.org/uniprotkb/Q13415/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ORC1","url":"https://civicdb.org/features/4046","note":"1 evidence items, 0 assertions, 1 variants; diseases: Triple-negative Breast Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:8487","ensembl":"ENSG00000085840","uniprot":"Q13415","entrez":"4998","biology":"Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Location: Nucleus (UniProt). Locus 1p32.3 (HGNC).","whereFound":["Triple-negative breast cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/orc1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}]}}