{"entity":{"id":"orlucent-system","kind":"drug","name":"Orlucent System","aka":["ORL1","Orlucent Skin Fluorescent Imaging System"],"tldr":"The Orlucent System is a handheld skin imager from Orlucent that uses a fluorescent agent to judge whether a mole may be becoming melanoma. It is in clinical trials and for research use only in the United States.","summary":"The Orlucent System from Orlucent is a handheld fluorescent molecular imaging system that assesses the likelihood of a mole's transition to melanoma; the company states it is in clinical trials and for research use only in the United States. Its imaging agent ORL1 is the subject of NCI SBIR grant 1R44CA306680-01A1, which funds manufacturing controls to current Good Manufacturing Practice and reports, from preliminary studies, 100 per cent sensitivity and 95.7 per cent specificity in distinguishing melanomas from non-melanomas.","asOf":"2026-11-04","links":[{"label":"Orlucent","url":"https://orlucent.com/"},{"label":"NIH RePORTER: award 1R44CA306680-01A1","url":"https://reporter.nih.gov/project-details/11410547"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":["imaging","early-detection"],"technologies":["optical-imaging"],"targets":[],"drugs":[],"companies":["orlucent"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors","editedOn":"2026-11-04"},"modality":"Handheld fluorescent molecular skin imaging system with topical imaging agent (device)","mechanism":"A fluorescent imaging agent, ORL1, is applied to a skin lesion and a handheld imager reads its signal to assess molecular changes linked to melanoma, as described by the company and its NCI award.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/orlucent-system/","neighbours":{"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"},{"id":"imaging","kind":"section","name":"Imaging","route":"/fronts/imaging/"}],"technology":[{"id":"optical-imaging","kind":"technology","name":"Optical & fluorescence imaging","route":"/technologies/optical-imaging/"}],"company":[{"id":"orlucent","kind":"company","name":"Orlucent","route":"/companies/orlucent/"}]}}