{"entity":{"id":"osbpl10","kind":"target","name":"OSBPL10","aka":["oxysterol binding protein like 10","Oxysterol-binding protein-related protein 10"],"tldr":"OSBPL10 (Oxysterol-binding protein-related protein 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16395","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16395"},{"label":"UniProt Q9BXB5","url":"https://www.uniprot.org/uniprotkb/Q9BXB5/entry"},{"label":"NCBI Gene 114884","url":"https://www.ncbi.nlm.nih.gov/gene/114884"},{"label":"Ensembl ENSG00000144645","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144645"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"OSBPL10","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:16395","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16395","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BXB5","url":"https://www.uniprot.org/uniprotkb/Q9BXB5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene OSBPL10","url":"https://civicdb.org/features/17340","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"hgnc":"HGNC:16395","ensembl":"ENSG00000144645","uniprot":"Q9BXB5","entrez":"114884","biology":"Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localises at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex. Negatively regulates APOB secretion from hepatocytes. Location: Cytoplasm, cytoskeleton; Late endosome membrane; Golgi apparatus, trans-Golgi network membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane (UniProt). Locus 3p23 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/osbpl10/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}