{"entity":{"id":"pabpc1","kind":"target","name":"PABPC1","aka":["poly(A) binding protein cytoplasmic 1","Polyadenylate-binding protein 1","PABP1","PABPL1","PAB1","PABPC2"],"tldr":"PABPC1 (Polyadenylate-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Bladder & urothelial cancer and 5 more.","summary":"Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.69). IntOGen calls it a driver in 8 cohorts (8 activating, 0 loss-of-function), covering Basal Cell Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Plasma Cell Myeloma, Upper Tract Urothelial Carcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8554","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8554"},{"label":"UniProt P11940","url":"https://www.uniprot.org/uniprotkb/P11940/entry"},{"label":"NCBI Gene 26986","url":"https://www.ncbi.nlm.nih.gov/gene/26986"},{"label":"Ensembl ENSG00000070756","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000070756"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","multiple-myeloma","urothelial","thyroid","dlbcl","basal-cell-carcinoma","nsclc","papillary-thyroid-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 8 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PABPC1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:8554","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8554","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P11940","url":"https://www.uniprot.org/uniprotkb/P11940/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000070756","url":"https://platform.opentargets.org/target/ENSG00000070756/associations","note":"association with cancer (MONDO_0004992) 0.59;  (GraphQL API, CC0)"},{"label":"IntOGen PABPC1","url":"https://www.intogen.org/search?gene=PABPC1","note":"driver in 8 cohorts (Act 8, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8554","ensembl":"ENSG00000070756","uniprot":"P11940","entrez":"26986","biology":"Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Location: Cytoplasm; Cytoplasm, Stress granule; Nucleus; Cell projection, lamellipodium (UniProt). Locus 8q22.3 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC)","Thyroid cancer: IntOGen driver in 1 cohort (WDTC)","Diffuse large B-cell lymphoma: IntOGen driver in 2 cohorts (DLBCLNOS)","Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/pabpc1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"papillary-thyroid-cancer","kind":"cancer","name":"Papillary thyroid cancer","route":"/cancers/papillary-thyroid-cancer/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}