{"entity":{"id":"pald1","kind":"target","name":"PALD1","aka":["phosphatase domain containing paladin 1","Paladin","KIAA1274"],"tldr":"PALD1 (Paladin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma.","summary":"UniProt has no function text for Q9ULE6; HGNC names it \"phosphatase domain containing paladin 1\".\n\n","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23530","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23530"},{"label":"UniProt Q9ULE6","url":"https://www.uniprot.org/uniprotkb/Q9ULE6/entry"},{"label":"NCBI Gene 27143","url":"https://www.ncbi.nlm.nih.gov/gene/27143"},{"label":"Ensembl ENSG00000107719","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107719"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PALD1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23530","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23530","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9ULE6","url":"https://www.uniprot.org/uniprotkb/Q9ULE6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000107719","url":"https://platform.opentargets.org/target/ENSG00000107719/associations","note":"per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:23530","ensembl":"ENSG00000107719","uniprot":"Q9ULE6","entrez":"27143","biology":"UniProt has no function text for Q9ULE6; HGNC names it \"phosphatase domain containing paladin 1\". Location: Cytoplasm, cytosol (UniProt). Locus 10q22.1 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908)"],"targetClass":"other","prevalence":[]},"route":"/targets/pald1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}