{"entity":{"id":"pamrevlumab","kind":"drug","name":"Pamrevlumab","aka":["FG-3019"],"tldr":"Pamrevlumab targeted the scar-like tissue around pancreatic tumours; its phase 3 LAPIS trial in locally advanced disease did not lengthen survival.","summary":"FibroGen developed pamrevlumab for fibrotic diseases and for pancreatic cancer, where connective tissue growth factor helps build the stroma that shields tumour cells. A phase 1/2 study suggested more patients could reach surgery.\n\nThe phase 3 LAPIS trial in locally advanced unresectable pancreatic cancer, combined with gemcitabine and nab-paclitaxel or FOLFIRINOX, did not meet its overall survival endpoint, reported in 2024. A metastatic arm within the Precision Promise platform trial was also stopped for futility, ending the programme.","status":"negative","asOf":"2026-09-17","links":[{"label":"ClinicalTrials.gov NCT03941093","url":"https://clinicaltrials.gov/study/NCT03941093"},{"label":"FibroGen announcement, LAPIS topline results (2024)","url":"https://investor.fibrogen.com/news-releases"}],"tags":[],"related":[],"cancers":["pancreatic"],"sections":[],"technologies":["monoclonal-antibody"],"targets":[],"drugs":[],"companies":["fibrogen"],"institutions":[],"pathways":[],"terms":[],"trials":["lapis-trial"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"code":"FG-3019","modality":"Monoclonal antibody against connective tissue growth factor (CTGF)","mechanism":"Binds connective tissue growth factor, a driver of the dense fibrous stroma that surrounds pancreatic tumours, aiming to make them more resectable and more permeable to chemotherapy.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/pamrevlumab/","neighbours":{"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"technology":[{"id":"monoclonal-antibody","kind":"technology","name":"Monoclonal antibodies","route":"/technologies/monoclonal-antibody/"}],"company":[{"id":"fibrogen","kind":"company","name":"FibroGen","route":"/companies/fibrogen/"}],"trial":[{"id":"lapis-trial","kind":"trial","name":"LAPIS","route":"/trials/lapis-trial/"},{"id":"precision-promise","kind":"trial","name":"Precision Promise","route":"/trials/precision-promise/"}]}}