{"entity":{"id":"pap","kind":"target","name":"Prostatic acid phosphatase (ACP3, PAP)","aka":[],"tldr":"Prostatic acid phosphatase is an enzyme made almost only by the prostate; the cell vaccine sipuleucel-T trains a patient's immune cells against it.","summary":"Prostatic acid phosphatase (PAP, gene ACP3) is secreted by prostate epithelium and was the prostate cancer blood marker before PSA. Because it is nearly prostate-specific, it serves as the antigen for sipuleucel-T: the patient's antigen-presenting cells are loaded with a PAP-GM-CSF fusion protein and re-infused to raise an anti-PAP immune response in metastatic castration-resistant prostate cancer.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Prostatic_acid_phosphatase","links":[{"label":"UniProt P15309: ACP3","url":"https://www.uniprot.org/uniprotkb/P15309/entry"},{"label":"HGNC:125 ACP3","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:125"},{"label":"ChEMBL target CHEMBL2633","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2633"}],"tags":[],"related":[],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":["sipuleucel-t"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"ACP3","biology":"A prostate-restricted phosphatase found in secreted and transmembrane forms; expression persists in most prostate cancers.","whereFound":["Prostate epithelium and prostate cancer (most cases)","Low in other tissues"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/pap/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"drug":[{"id":"sipuleucel-t","kind":"drug","name":"Sipuleucel-T","route":"/drugs/sipuleucel-t/"}]}}