{"entity":{"id":"paper-aall0031-imatinib-ph-positive-all-schultz-jco-2009","kind":"paper","name":"AALL0031: imatinib with intensive chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leukaemia in children","aka":[],"tldr":"Adding continuous imatinib to intensive chemotherapy more than doubled three-year event-free survival in childhood Philadelphia-positive leukaemia compared with historical controls and matched the results of transplant, changing the standard of care.","summary":"Children's Oncology Group study of 92 children with Ph-positive ALL treated with intensive chemotherapy plus imatinib for increasing durations across cohorts, with transplant for those with a sibling donor.\n\nThree-year event-free survival in the cohort with continuous imatinib was 80 percent, more than double the 35 percent of historical controls, and no worse than with sibling donor transplant; toxicity was not increased.","asOf":"2026-09-17","links":[{"label":"J Clin Oncol 2009","url":"https://doi.org/10.1200/JCO.2008.21.2514"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/19805687/"}],"tags":[],"related":[],"cancers":["all-paediatric-ph-positive"],"sections":[],"technologies":[],"targets":[],"drugs":["imatinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2009,"doi":"10.1200/JCO.2008.21.2514","pmid":"19805687","authors":"Schultz KR, Bowman WP, Aledo A, et al.","paperType":"observational","findings":["Three-year event-free survival 80 percent with continuous imatinib vs 35 percent in historical controls.","Chemotherapy plus imatinib comparable to sibling donor transplant."],"whatItMeans":"A tyrosine kinase inhibitor throughout chemotherapy is the standard for childhood Ph-positive ALL, and transplant in first remission is no longer routine.","caveats":["Non-randomised comparison with historical controls; small cohorts."],"changedPractice":true,"participants":92},"route":"/key-papers/paper-aall0031-imatinib-ph-positive-all-schultz-jco-2009/","neighbours":{"cancer":[{"id":"all-paediatric-ph-positive","kind":"cancer","name":"Philadelphia chromosome-positive acute lymphoblastic leukaemia in children (Ph-positive ALL)","route":"/cancers/all-paediatric-ph-positive/"}],"drug":[{"id":"imatinib","kind":"drug","name":"Imatinib","route":"/drugs/imatinib/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}