{"entity":{"id":"paper-ajcc-8-melanoma-gershenwald-ca-2017","kind":"paper","name":"Melanoma staging: evidence-based changes in the AJCC eighth edition cancer staging manual","aka":[],"tldr":"The eighth-edition melanoma staging system, derived from over 46,000 patients, refined thickness cut-offs and node categories and created the stage IIIA to IIID subgroups whose very different outlooks now guide adjuvant therapy decisions.","summary":"Description of the American Joint Committee on Cancer eighth-edition staging for melanoma, based on an international database of 46,000 patients, including changes to T1 subcategories, removal of mitotic rate from T1 staging, revised N categories incorporating microsatellites and in-transit disease, new stage III subgroups, and M1 subcategories with lactate dehydrogenase.","asOf":"2026-09-17","links":[{"label":"CA Cancer J Clin 2017","url":"https://doi.org/10.3322/caac.21409"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/29028110/"}],"tags":[],"related":[],"cancers":["stage-ii-melanoma","stage-iii-melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["ca-cancer-journal"],"dependsOn":[],"notes":[],"journal":"CA: A Cancer Journal for Clinicians","year":2017,"doi":"10.3322/caac.21409","pmid":"29028110","authors":"Gershenwald JE, Scolyer RA, Hess KR, et al.","paperType":"guideline","findings":["Five-year melanoma-specific survival ranges from 93 percent in stage IIIA to 32 percent in stage IIID.","Stage IIB and IIC have worse survival than stage IIIA."],"whatItMeans":"Stage IIB, IIC and III on this site's melanoma pages, and the recognition that stage IIIA has a better prognosis than stage IIB or IIC, come from this system.","caveats":["Survival estimates predate modern adjuvant therapy."],"changedPractice":true},"route":"/key-papers/paper-ajcc-8-melanoma-gershenwald-ca-2017/","neighbours":{"cancer":[{"id":"stage-ii-melanoma","kind":"cancer","name":"Stage IIB and IIC melanoma","route":"/cancers/stage-ii-melanoma/"},{"id":"stage-iii-melanoma","kind":"cancer","name":"Stage III melanoma (after surgery)","route":"/cancers/stage-iii-melanoma/"}],"journal":[{"id":"ca-cancer-journal","kind":"journal","name":"CA: A Cancer Journal for Clinicians","route":"/journals/ca-cancer-journal/"}]}}