{"entity":{"id":"paper-aktipis-philos-trans-r-soc-lond-b-biol-sci","kind":"paper","name":"Cancer across the tree of life: cooperation and cheating in multicellularity","aka":[],"tldr":"Paper cited by one term page, indexed on Europe PMC as PubMed record 26056363 and published in Philosophical transactions of the Royal Society of London. Series B, Biological sciences; the citing page links this DOI, which is how the record was matched.","summary":"Multicellularity is characterized by cooperation among cells for the development, maintenance and reproduction of the multicellular organism. Cancer can be viewed as cheating within this cooperative multicellular system. Complex multicellularity, and the cooperation underlying it, has evolved independently multiple times. We review the existing literature on cancer and cancer-like phenomena across life, not only focusing on complex multicellularity but also reviewing cancer-like phenomena across the tree of life more broadly. We find that cancer is characterized by a breakdown of the central features of cooperation that characterize multicellularity, including cheating in proliferation inhibition, cell death, division of labour, resource allocation and extracellular environment maintenance (which we term the five foundations of multicellularity). Cheating on division of labour, exhibited by a lack of differentiation and disorganized cell masses, has been observed in all forms of multicellularity. This suggests that deregulation of differentiation is a fundamental and universal aspect of carcinogenesis that may be underappreciated in cancer biology. Understanding cancer as a breakdown of multicellular cooperation provides novel insights into cancer hallmarks and suggests a set of assays and biomarkers that can be applied across species and characterize the fundamental requirements for generating a cancer.\n\nIndexed on Europe PMC as PubMed record 26056363 (DOI 10.1098/rstb.2014.0219). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Philos Trans R Soc Lond B Biol Sci 2015","url":"https://doi.org/10.1098/rstb.2014.0219"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/26056363/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/26056363"}],"tags":["europepmc-ingest"],"related":["atavistic-theory-of-cancer"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","year":2015,"doi":"10.1098/rstb.2014.0219","pmid":"26056363","authors":"Aktipis CA, Boddy AM, Jansen G, et al.","paperType":"review","findings":[],"whatItMeans":"One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-aktipis-philos-trans-r-soc-lond-b-biol-sci/","neighbours":{"term":[{"id":"atavistic-theory-of-cancer","kind":"term","name":"Atavistic theory: cancer as a reversion to an ancient programme","route":"/terms/atavistic-theory-of-cancer/"}]}}