{"entity":{"id":"paper-anthony-nichols-nat-genet-2014","kind":"paper","name":"Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands","aka":[],"tldr":"Paper by Anthony C. Nichols indexed on Europe PMC as PubMed record 25240283, in Nature Genetics (2014), one of the most cited records naming an author with this name at Verspeeten Family Cancer Centre, London Health Sciences Centre.","summary":"Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.\n\nIndexed on Europe PMC as PubMed record 25240283 (DOI 10.1038/ng.3096). Its author list gives \"Nichols AC\" with the affiliation \"Western University, London, Ontario, Canada\", which names Verspeeten Family Cancer Centre, London Health Sciences Centre; that is how the record was matched to Anthony C. Nichols, and no figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Nat Genet 2014","url":"https://doi.org/10.1038/ng.3096"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/25240283/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/25240283"}],"tags":["europepmc-ingest"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["anthony-nichols"],"bottlenecks":[],"keyPapers":[],"journals":["nature-genetics"],"dependsOn":[],"notes":[],"journal":"Nature Genetics","year":2014,"doi":"10.1038/ng.3096","pmid":"25240283","authors":"Weinreb I, Piscuoglio S, Martelotto LG, et al.","paperType":"observational","findings":[],"whatItMeans":"One of the most cited papers Europe PMC returns for Anthony C. Nichols at Verspeeten Family Cancer Centre, London Health Sciences Centre, so it is a natural starting point for reading their work. The record was linked automatically from the author list and affiliation; read the abstract above and the paper itself before relying on any figure.","caveats":["Matched to the person by surname, initials and an affiliation string naming the institution on the Europe PMC record; the summary reproduces the record's abstract and no figure has been verified against the full paper.","Two authors sharing a surname, initials and institution cannot be told apart by this method; the person's profile links are the place to confirm authorship."]},"route":"/key-papers/paper-anthony-nichols-nat-genet-2014/","neighbours":{"person":[{"id":"anthony-nichols","kind":"person","name":"Anthony C. Nichols","route":"/people/anthony-nichols/"}],"journal":[{"id":"nature-genetics","kind":"journal","name":"Nature Genetics","route":"/journals/nature-genetics/"}]}}