{"entity":{"id":"paper-ata-anaplastic-thyroid-guideline-bible-thyroid-2021","kind":"paper","name":"2021 American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer","aka":[],"tldr":"The updated American guideline for anaplastic thyroid cancer stresses molecular testing within days of diagnosis, BRAF-MEK inhibitors for BRAF-mutant disease including before surgery, multimodal therapy for resectable disease, and early goals-of-care discussions.","summary":"Evidence-based guideline covering rapid diagnosis and staging, airway management, molecular testing, surgery, radiotherapy with or without chemotherapy, BRAF-directed and other targeted therapy, immunotherapy, and palliative and supportive care for anaplastic thyroid cancer.","asOf":"2026-09-17","links":[{"label":"Thyroid 2021","url":"https://doi.org/10.1089/thy.2020.0944"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/33728999/"}],"tags":[],"related":[],"cancers":["anaplastic-thyroid-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Thyroid","year":2021,"doi":"10.1089/thy.2020.0944","pmid":"33728999","authors":"Bible KC, Kebebew E, Brierley J, et al.","paperType":"guideline","findings":[],"whatItMeans":"The anaplastic thyroid cancer page's emphasis on speed, BRAF testing and neoadjuvant targeted therapy follows this guideline.","caveats":["Evidence for most recommendations is from small series."],"changedPractice":true},"route":"/key-papers/paper-ata-anaplastic-thyroid-guideline-bible-thyroid-2021/","neighbours":{"cancer":[{"id":"anaplastic-thyroid-cancer","kind":"cancer","name":"Anaplastic thyroid cancer","route":"/cancers/anaplastic-thyroid-cancer/"}]}}