{"entity":{"id":"paper-barth-phyllodes-adjuvant-radiotherapy-ann-surg-oncol-2009","kind":"paper","name":"Prospective multi-institutional study of adjuvant radiotherapy after resection of borderline and malignant phyllodes tumours","aka":[],"tldr":"In a prospective study, no woman whose borderline or malignant phyllodes tumour was excised with clear margins and then given radiotherapy had a local recurrence, supporting radiotherapy after breast-conserving surgery for these tumours.","summary":"Prospective study of 46 women with borderline or malignant phyllodes tumours treated with margin-negative breast-conserving resection followed by adjuvant radiotherapy.\n\nWith a median follow-up of 56 months there were no local recurrences, compared with historical local recurrence rates of 15 to 30 percent after surgery alone, though distant metastases occurred in a small number of malignant cases.","asOf":"2026-09-17","links":[{"label":"Ann Surg Oncol 2009","url":"https://doi.org/10.1245/s10434-009-0489-2"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/19424757/"}],"tags":[],"related":[],"cancers":["phyllodes-tumour"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["annals-of-surgical-oncology"],"dependsOn":[],"notes":[],"journal":"Annals of surgical oncology","year":2009,"doi":"10.1245/s10434-009-0489-2","pmid":"19424757","authors":"Barth RJ, Wells WA, Mitchell SE, et al.","paperType":"observational","findings":["Local recurrence 0 percent at a median of 56 months after resection plus radiotherapy."],"whatItMeans":"Adjuvant radiotherapy is considered after breast conservation for borderline and malignant phyllodes tumours; it does not address the risk of distant spread.","caveats":["Small, non-randomised study with a historical comparison."],"changedPractice":true,"participants":46},"route":"/key-papers/paper-barth-phyllodes-adjuvant-radiotherapy-ann-surg-oncol-2009/","neighbours":{"cancer":[{"id":"phyllodes-tumour","kind":"cancer","name":"Phyllodes tumour of the breast","route":"/cancers/phyllodes-tumour/"}],"journal":[{"id":"annals-of-surgical-oncology","kind":"journal","name":"Annals of surgical oncology","route":"/journals/annals-of-surgical-oncology/"}]}}