{"entity":{"id":"paper-best-tumour-educated-platelets-cancer-cell-2015","kind":"paper","name":"RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics","aka":[],"tldr":"The first study to show that RNA inside blood platelets changes enough with cancer to tell people with cancer from healthy people.","summary":"mRNA sequencing of 283 platelet samples distinguished 228 patients with localised and metastasised tumours from 55 healthy individuals with 96 per cent accuracy, and the location of the primary tumour was correctly identified with 71 per cent accuracy across six tumour types.","asOf":"2026-11-04","links":[{"label":"Best et al., Cancer Cell 2015","url":"https://doi.org/10.1016/j.ccell.2015.09.018"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/26525104/"}],"tags":[],"related":[],"cancers":[],"sections":["early-detection","diagnostics"],"technologies":["liquid-rna-biopsy","mced"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Cancer Cell","year":2015,"doi":"10.1016/j.ccell.2015.09.018","pmid":"26525104","authors":"Best MG, Sol N, Kooi I, et al.","paperType":"translational","findings":["96% accuracy, cancer against healthy.","71% accuracy for the primary site."],"whatItMeans":"Platelets carry a readable record of a tumour's presence.","caveats":["Healthy controls, not people with other illnesses; later work found more false positives in ill controls."],"participants":283},"route":"/key-papers/paper-best-tumour-educated-platelets-cancer-cell-2015/","neighbours":{"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"},{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}],"drug":[{"id":"thromboseq","kind":"drug","name":"thromboSeq (tumour-educated platelet RNA)","route":"/drugs/thromboseq/"}]}}