{"entity":{"id":"paper-bolouri-paediatric-aml-genomics-nat-med-2018","kind":"paper","name":"The molecular landscape of paediatric acute myeloid leukaemia (TARGET)","aka":[],"tldr":"Sequencing nearly a thousand childhood acute myeloid leukaemias showed the disease differs sharply from adult disease, with fewer mutations, more structural rearrangements and age-specific drivers, so adult genetic risk groups cannot simply be transferred to children.","summary":"Comprehensive genomic study by the TARGET initiative of 993 children and young adults with AML, including whole-genome, exome, transcriptome and methylation profiling, identifying age-specific patterns of somatic mutations, structural variants such as KMT2A and NUP98 rearrangements, and novel focal deletions.","asOf":"2026-09-17","links":[{"label":"Nat Med 2018","url":"https://doi.org/10.1038/nm.4439"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/29227476/"}],"tags":[],"related":[],"cancers":["aml-paediatric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-medicine"],"dependsOn":[],"notes":[],"journal":"Nature Medicine","year":2018,"doi":"10.1038/nm.4439","pmid":"29227476","authors":"Bolouri H, Farrar JE, Triche T, et al.","paperType":"translational","findings":["Low mutation burden in childhood AML with structural variants and fusions predominating.","Distinct age-associated mutations, for example NPM1 and DNMT3A being rare in young children."],"whatItMeans":"Paediatric AML risk classification and targeted therapy development now rest on this landscape rather than on adult data.","caveats":["Discovery cohort; clinical translation into risk stratification is ongoing."],"changedPractice":true,"participants":993},"route":"/key-papers/paper-bolouri-paediatric-aml-genomics-nat-med-2018/","neighbours":{"cancer":[{"id":"aml-paediatric","kind":"cancer","name":"Acute myeloid leukaemia in children","route":"/cancers/aml-paediatric/"}],"journal":[{"id":"nature-medicine","kind":"journal","name":"Nature Medicine","route":"/journals/nature-medicine/"}]}}