{"entity":{"id":"paper-bonvalot-retroperitoneal-sarcoma-compartmental-jco-2009","kind":"paper","name":"Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control","aka":[],"tldr":"This French multicentre study showed that resecting a retroperitoneal sarcoma together with the adjacent organs, even when not obviously involved, reduced local recurrence more than threefold, establishing the compartmental surgical approach.","summary":"Retrospective analysis of 382 patients with primary retroperitoneal sarcoma from French Sarcoma Group centres examining surgical technique, margins and outcomes.\n\nSystematic en bloc resection of adjacent organs (compartmental resection) was associated with a 3.29-fold lower risk of abdominal recurrence compared with simple complete resection, without higher mortality, while incomplete resection and high grade predicted recurrence.","asOf":"2026-09-17","links":[{"label":"J Clin Oncol 2009","url":"https://doi.org/10.1200/JCO.2008.18.0802"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/19047280/"}],"tags":[],"related":[],"cancers":["retroperitoneal-sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2009,"doi":"10.1200/JCO.2008.18.0802","pmid":"19047280","authors":"Bonvalot S, Rivoire M, Castaing M, et al.","paperType":"observational","findings":["Abdominal recurrence risk reduced 3.29-fold with compartmental resection.","Postoperative mortality 3 percent."],"whatItMeans":"Extended en bloc resection in a sarcoma reference centre is the standard operation for retroperitoneal sarcoma.","caveats":["Retrospective; extended resection carries morbidity and remains debated for low-grade liposarcoma."],"changedPractice":true,"participants":382},"route":"/key-papers/paper-bonvalot-retroperitoneal-sarcoma-compartmental-jco-2009/","neighbours":{"cancer":[{"id":"retroperitoneal-sarcoma","kind":"cancer","name":"Retroperitoneal sarcoma","route":"/cancers/retroperitoneal-sarcoma/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}