{"entity":{"id":"paper-cheng-oncomine-dx-express-validation-mol-diagn-ther-2026","kind":"paper","name":"Analytical and Clinical Validation of the Oncomine Dx Express Test, an In Vitro Diagnostic-Labeled Assay, for Genomic Profiling of FFPE Tumor Samples","aka":[],"tldr":"The validation of Thermo Fisher's tissue sequencing test, which reads DNA and RNA from the same small sample.","summary":"In 462 fixed tumour samples, agreement with orthogonal methods for RNA variants (fusions and splice variants) was 95.9 per cent positive and 100 per cent negative; RNA repeatability ranged from 88.9 per cent (ALK fusion) to 100 per cent.","asOf":"2026-11-04","links":[{"label":"Cheng et al., Mol Diagn Ther 2026","url":"https://doi.org/10.1007/s40291-026-00884-z"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/42848264/"}],"tags":[],"related":[],"cancers":[],"sections":["diagnostics"],"technologies":["rna-seq","companion-diagnostic"],"targets":[],"drugs":["oncomine-dx-express"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Molecular Diagnosis and Therapy","year":2026,"doi":"10.1007/s40291-026-00884-z","pmid":"42848264","authors":"Cheng A, Nallu S, He L, et al.","paperType":"translational","findings":["RNA variants: positive agreement 95.9%, negative agreement 100%."],"whatItMeans":"Approved tissue tests now read RNA fusions alongside DNA in one run.","caveats":["Industry-sponsored."],"participants":462},"route":"/key-papers/paper-cheng-oncomine-dx-express-validation-mol-diagn-ther-2026/","neighbours":{"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"companion-diagnostic","kind":"technology","name":"Companion diagnostics","route":"/technologies/companion-diagnostic/"},{"id":"rna-seq","kind":"technology","name":"RNA sequencing & expression profiling","route":"/technologies/rna-seq/"}],"drug":[{"id":"oncomine-dx-express","kind":"drug","name":"Oncomine Dx Express Test","route":"/drugs/oncomine-dx-express/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}