{"entity":{"id":"paper-chicago-consensus-appendiceal-neoplasms-cancer-2020","kind":"paper","name":"The Chicago Consensus on peritoneal surface malignancies: management of appendiceal neoplasms","aka":[],"tldr":"A multidisciplinary consensus laying out treatment pathways for each kind of appendix tumour, from low-grade mucinous neoplasms to adenocarcinoma and goblet cell adenocarcinoma, including when cytoreductive surgery with heated chemotherapy and when systemic chemotherapy are appropriate.","summary":"Consensus from the Chicago Consensus Working Group of surgical, medical and pathological oncologists giving management algorithms for appendiceal neoplasms: LAMN with and without peritoneal disease, high-grade mucinous neoplasm, mucinous and non-mucinous adenocarcinoma, and goblet cell adenocarcinoma.\n\nIt recommends cytoreductive surgery with HIPEC for peritoneal disease in centres with expertise, systemic chemotherapy based on colorectal regimens for high-grade and adenocarcinoma histologies, and observation for low-grade disease confined to the appendix.","asOf":"2026-09-18","links":[{"label":"Cancer 2020","url":"https://doi.org/10.1002/cncr.32881"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/32282073/"}],"tags":[],"related":[],"cancers":["appendiceal-adenocarcinoma","goblet-cell-adenocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["mitomycin","folfox","capox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancer-wiley"],"dependsOn":[],"notes":[],"journal":"Cancer","year":2020,"doi":"10.1002/cncr.32881","pmid":"32282073","authors":"Chicago Consensus Working Group.","paperType":"guideline","findings":[],"whatItMeans":"The standard-of-care rows on the appendiceal pages, particularly who is referred for cytoreductive surgery and who receives chemotherapy, follow this consensus and the NCCN appendiceal section.","caveats":["Consensus on limited retrospective evidence; no randomised trial has tested chemotherapy in appendiceal adenocarcinoma at the time of writing.","Applies to centres with peritoneal surface malignancy expertise."],"changedPractice":false},"route":"/key-papers/paper-chicago-consensus-appendiceal-neoplasms-cancer-2020/","neighbours":{"cancer":[{"id":"appendiceal-adenocarcinoma","kind":"cancer","name":"Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell)","route":"/cancers/appendiceal-adenocarcinoma/"},{"id":"goblet-cell-adenocarcinoma","kind":"cancer","name":"Goblet cell adenocarcinoma of the appendix","route":"/cancers/goblet-cell-adenocarcinoma/"}],"drug":[{"id":"capox","kind":"drug","name":"CAPOX (capecitabine, oxaliplatin)","route":"/drugs/capox/"},{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"},{"id":"mitomycin","kind":"drug","name":"Mitomycin C","route":"/drugs/mitomycin/"}],"journal":[{"id":"cancer-wiley","kind":"journal","name":"Cancer","route":"/journals/cancer-wiley/"}]}}