{"entity":{"id":"paper-church-pole-endometrial-jnci-2015","kind":"paper","name":"Prognostic significance of POLE proofreading mutations in endometrial cancer","aka":[],"tldr":"Endometrial cancers with mutations in the proofreading domain of POLE, though hypermutated and often high grade, almost never recur, identifying a group of women who can be spared adjuvant treatment.","summary":"Analysis of 788 endometrial cancers from the PORTEC-1 and PORTEC-2 trials for POLE exonuclease domain mutations, found in 6.1 percent, with survival analysis and a meta-analysis of published series.\n\nPOLE-mutant tumours were more often high grade yet had excellent recurrence-free survival (hazard ratio 0.14) and cancer-specific survival, independent of other prognostic factors.","asOf":"2026-09-17","links":[{"label":"J Natl Cancer Inst 2015","url":"https://doi.org/10.1093/jnci/dju402"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/25505230/"}],"tags":[],"related":[],"cancers":["endometrial-pole-ultramutated"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jnci"],"dependsOn":[],"notes":[],"journal":"JNCI: Journal of the National Cancer Institute","year":2015,"doi":"10.1093/jnci/dju402","pmid":"25505230","authors":"Church DN, Stelloo E, Nout RA, et al.","paperType":"translational","findings":["POLE exonuclease domain mutations in 6.1 percent of tumours.","Recurrence-free survival hazard ratio 0.14 for POLE-mutant tumours."],"whatItMeans":"POLE sequencing is now part of endometrial cancer classification, and guidelines allow omission of adjuvant therapy for stage I to II POLE-mutated tumours.","caveats":["Retrospective analysis of trial cohorts; only pathogenic hotspot mutations carry the favourable prognosis."],"changedPractice":true,"participants":788},"route":"/key-papers/paper-church-pole-endometrial-jnci-2015/","neighbours":{"cancer":[{"id":"endometrial-pole-ultramutated","kind":"cancer","name":"POLE-ultramutated endometrial cancer","route":"/cancers/endometrial-pole-ultramutated/"}],"journal":[{"id":"jnci","kind":"journal","name":"JNCI: Journal of the National Cancer Institute","route":"/journals/jnci/"}]}}