{"entity":{"id":"paper-cillessen-psychooncology","kind":"paper","name":"Mindfulness-based interventions for psychological and physical health outcomes in cancer patients and survivors: A systematic review and meta-analysis of randomized controlled trials","aka":[],"tldr":"Paper cited by one technology page, indexed on Europe PMC as PubMed record 31464026 and published in Psycho-oncology; the citing page links this DOI, which is how the record was matched.","summary":"Objective: Mindfulness-based interventions (MBIs) are increasingly used within psycho-oncology. Since the publication of the most recent comprehensive meta-analysis on MBIs in cancer in 2012, the number of published trials has more than doubled. We therefore conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), testing the efficacy of MBIs on measures of psychological distress (primary outcome) and other health outcomes in cancer patients and survivors.\n\nMethods: Two authors conducted independent literature searches in electronic databases from first available date to 10 October 2018, selected eligible studies, extracted data for meta-analysis, and evaluated risk of bias.\n\nResults: Twenty-nine independent RCTs (reported in 38 papers) with 3274 participants were included. Small and statistically significant pooled effects of MBIs on combined measures of psychological distress were found at post-intervention (Hedges's g = 0.32; 95%CI: 0.22-0.41; P <.001) and follow-up (g = 0.19; 95%CI: 0.07-0.30; P <.002). Statistically significant effects were also found at either post-intervention or follow-up for a range of self-reported secondary outcomes, including anxiety, depression, fear of cancer recurrence, fatigue, sleep disturbances, and pain (g: 0.20 to 0.51; p: <.001 to.047). Larger effects of MBIs on psychological distress were found in studies (a) adhering to the original MBI manuals, (b) with younger patients, (c) with passive control conditions, and (d) shorter time to follow-up. Improvements in mindfulness skills were associated with greater reductions in psychological distress at post-intervention.\n\nConclusions: MBIs appear efficacious in reducing psychological distress and other symptoms in cancer patients and survivors. However, many of the effects were of small magnitude, suggesting a need for intervention optimization research.\n\nIndexed on Europe PMC as PubMed record 31464026 (DOI 10.1002/pon.5214). Matched by DOI alone: one technology page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Psychooncology 2019","url":"https://doi.org/10.1002/pon.5214"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/31464026/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/31464026"}],"tags":["europepmc-ingest"],"related":["mindfulness-based-interventions"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["psycho-oncology-journal"],"dependsOn":[],"notes":[],"journal":"Psycho-oncology","year":2019,"doi":"10.1002/pon.5214","pmid":"31464026","authors":"Cillessen L, Johannsen M, Speckens AEM, et al.","paperType":"meta-analysis","findings":[],"whatItMeans":"One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-cillessen-psychooncology/","neighbours":{"technology":[{"id":"mindfulness-based-interventions","kind":"technology","name":"Mindfulness-based stress reduction and cognitive therapy","route":"/technologies/mindfulness-based-interventions/"}],"journal":[{"id":"psycho-oncology-journal","kind":"journal","name":"Psycho-oncology","route":"/journals/psycho-oncology-journal/"}]}}