{"entity":{"id":"paper-clark-syt-ssx-synovial-sarcoma-nat-genet-1994","kind":"paper","name":"Identification of SYT and SSX, the genes fused by the t(X;18) translocation in synovial sarcoma","aka":[],"tldr":"This study cloned the SYT-SSX (SS18-SSX) gene fusion produced by the chromosome translocation found in essentially every synovial sarcoma, giving the tumour a defining molecular marker and the basis for later targeted and immune therapies.","summary":"Molecular cloning of the t(X;18)(p11.2;q11.2) translocation breakpoint in synovial sarcoma, identifying the SYT gene on chromosome 18 fused to the SSX genes on the X chromosome and characterising the resulting fusion transcripts.","asOf":"2026-09-17","links":[{"label":"Nat Genet 1994","url":"https://doi.org/10.1038/ng0894-502"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/7951320/"}],"tags":[],"related":[],"cancers":["synovial-sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-genetics"],"dependsOn":[],"notes":[],"journal":"Nature Genetics","year":1994,"doi":"10.1038/ng0894-502","pmid":"7951320","authors":"Clark J, Rocques PJ, Crew AJ, et al.","paperType":"basic","findings":["SYT-SSX fusion identified as the product of t(X;18) in synovial sarcoma."],"whatItMeans":"SS18-SSX fusion testing confirms the diagnosis of synovial sarcoma, and the fusion's disruption of the BAF chromatin remodelling complex underlies experimental therapies such as BRD9 degraders; the tumour's MAGE-A4 and NY-ESO-1 expression enabled T-cell receptor therapy.","caveats":["Discovery paper; clinical translation came decades later."],"changedPractice":true},"route":"/key-papers/paper-clark-syt-ssx-synovial-sarcoma-nat-genet-1994/","neighbours":{"cancer":[{"id":"synovial-sarcoma","kind":"cancer","name":"Synovial sarcoma","route":"/cancers/synovial-sarcoma/"}],"journal":[{"id":"nature-genetics","kind":"journal","name":"Nature Genetics","route":"/journals/nature-genetics/"}]}}