{"entity":{"id":"paper-cowan-xpert-bladder-monitor-bju-int-2021","kind":"paper","name":"Longitudinal follow-up and performance validation of an mRNA-based urine test (Xpert Bladder Cancer Monitor) for surveillance in patients with non-muscle-invasive bladder cancer","aka":[],"tldr":"A longitudinal validation of a five-marker urine RNA test for bladder cancer follow-up.","summary":"The sensitivity for high-grade cancer was 87 per cent with a negative predictive value of 99 per cent.","asOf":"2026-11-04","links":[{"label":"Cowan et al., BJU Int 2021","url":"https://doi.org/10.1111/bju.15418"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/33793062/"}],"tags":[],"related":[],"cancers":["non-muscle-invasive-bladder-cancer"],"sections":["diagnostics"],"technologies":["liquid-rna-biopsy","urine-bladder-cancer-tests"],"targets":[],"drugs":["xpert-bladder-cancer-monitor"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"BJU International","year":2021,"doi":"10.1111/bju.15418","pmid":"33793062","authors":"Cowan B, Klein E, Jansz K, et al.","paperType":"translational","findings":["High-grade sensitivity 87%, negative predictive value 99%."],"whatItMeans":"A negative urine result makes a high-grade recurrence unlikely.","caveats":["Industry-sponsored."]},"route":"/key-papers/paper-cowan-xpert-bladder-monitor-bju-int-2021/","neighbours":{"cancer":[{"id":"non-muscle-invasive-bladder-cancer","kind":"cancer","name":"Non-muscle-invasive bladder cancer","route":"/cancers/non-muscle-invasive-bladder-cancer/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"},{"id":"urine-bladder-cancer-tests","kind":"technology","name":"Urine tests for bladder cancer (cytology, FISH, RNA and methylation)","route":"/technologies/urine-bladder-cancer-tests/"}],"drug":[{"id":"xpert-bladder-cancer-monitor","kind":"drug","name":"Xpert Bladder Cancer Monitor","route":"/drugs/xpert-bladder-cancer-monitor/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}