{"entity":{"id":"paper-dangelo-ny-eso-1-tcr-synovial-sarcoma-cancer-discov-2018","kind":"paper","name":"NY-ESO-1 c259 T-cell receptor therapy in synovial sarcoma: prolonged persistence and antitumour activity","aka":[],"tldr":"Engineering patients' own T cells with a receptor recognising the NY-ESO-1 antigen shrank tumours in half of a small group with advanced synovial sarcoma, the first convincing evidence that T-cell receptor therapy can work in a solid tumour.","summary":"Pilot study of 12 patients with HLA-A*02-positive, NY-ESO-1-expressing advanced synovial sarcoma treated with autologous T cells transduced with an affinity-enhanced NY-ESO-1 c259 T-cell receptor after lymphodepleting chemotherapy.\n\nObjective response was 50 percent including one complete response, with responses associated with T-cell persistence and higher lymphodepletion intensity; toxicity included cytokine release syndrome and cytopenias.","asOf":"2026-09-17","links":[{"label":"Cancer Discov 2018","url":"https://doi.org/10.1158/2159-8290.CD-17-1417"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/29891538/"}],"tags":[],"related":[],"cancers":["synovial-sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancer-discovery"],"dependsOn":[],"notes":[],"journal":"Cancer Discovery","year":2018,"doi":"10.1158/2159-8290.CD-17-1417","pmid":"29891538","authors":"D'Angelo SP, Melchiori L, Merchant MS, et al.","paperType":"observational","findings":["Objective response 6 of 12 patients (50 percent), one complete response.","Response correlated with T-cell persistence and lymphodepletion dose."],"whatItMeans":"This study opened the path to engineered T-cell receptor therapy in synovial sarcoma, leading to afamitresgene autoleucel targeting MAGE-A4 (SPEARHEAD-1) and its approval in 2024.","caveats":["Twelve patients; requires HLA-A*02 and antigen expression."],"changedPractice":true,"participants":12},"route":"/key-papers/paper-dangelo-ny-eso-1-tcr-synovial-sarcoma-cancer-discov-2018/","neighbours":{"cancer":[{"id":"synovial-sarcoma","kind":"cancer","name":"Synovial sarcoma","route":"/cancers/synovial-sarcoma/"}],"journal":[{"id":"cancer-discovery","kind":"journal","name":"Cancer Discovery","route":"/journals/cancer-discovery/"}]}}