{"entity":{"id":"paper-den-boer-bcr-abl1-like-all-lancet-oncol-2009","kind":"paper","name":"A subtype of childhood acute lymphoblastic leukaemia with poor outcome: genome-wide classification study (BCR-ABL1-like ALL)","aka":[],"tldr":"Gene expression profiling identified a group of childhood leukaemias that look like Philadelphia-positive disease without the fusion gene, later called Ph-like or BCR-ABL1-like ALL, with a high relapse rate and frequent IKZF1 deletions.","summary":"Genome-wide expression classification of 190 childhood B-ALL cases identifying a novel subtype in about 15 percent of B-other cases with a signature resembling BCR-ABL1-positive ALL, frequent IKZF1 deletions, and poor five-year disease-free survival (about 60 percent) validated in independent cohorts.","asOf":"2026-09-17","links":[{"label":"Lancet Oncol 2009","url":"https://doi.org/10.1016/S1470-2045(08)70339-5"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/19138562/"}],"tags":[],"related":[],"cancers":["all-ph-like"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["lancet-oncology"],"dependsOn":[],"notes":[],"journal":"The Lancet Oncology","year":2009,"doi":"10.1016/S1470-2045(08)70339-5","pmid":"19138562","authors":"Den Boer ML, van Slegtenhorst M, De Menezes RX, et al.","paperType":"translational","findings":["BCR-ABL1-like subtype in about 15 percent of B-other childhood ALL.","Five-year disease-free survival about 60 percent, similar to BCR-ABL1-positive ALL."],"whatItMeans":"This discovery, made simultaneously with the American Children's Oncology Group finding, created the Ph-like ALL category now screened for in high-risk protocols.","caveats":["Discovery study without kinase lesion characterisation, which came with later sequencing."],"changedPractice":true,"participants":190},"route":"/key-papers/paper-den-boer-bcr-abl1-like-all-lancet-oncol-2009/","neighbours":{"cancer":[{"id":"all-ph-like","kind":"cancer","name":"Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL)","route":"/cancers/all-ph-like/"}],"journal":[{"id":"lancet-oncology","kind":"journal","name":"The Lancet Oncology","route":"/journals/lancet-oncology/"}]}}