{"entity":{"id":"paper-denardo-nat-rev-immunol","kind":"paper","name":"Macrophages as regulators of tumour immunity and immunotherapy","aka":[],"tldr":"Paper cited by one pathway page, indexed on Europe PMC as PubMed record 30718830 and published in Nature reviews. Immunology; the citing page links this DOI, which is how the record was matched.","summary":"Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest in targeting macrophages in cancer, and preclinical studies have demonstrated efficacy across therapeutic modalities and tumour types. Much of the observed efficacy can be traced to the suppressive capacity of macrophages, driven by microenvironmental cues such as hypoxia and fibrosis. As a result, tumour macrophages display an ability to suppress T cell recruitment and function as well as to regulate other aspects of tumour immunity. With the increasing impact of cancer immunotherapy, macrophage targeting is now being evaluated in this context. Here, we discuss the results of clinical trials and the future of combinatorial immunotherapy.\n\nIndexed on Europe PMC as PubMed record 30718830 (DOI 10.1038/s41577-019-0127-6). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Nat Rev Immunol 2019","url":"https://doi.org/10.1038/s41577-019-0127-6"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/30718830/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/30718830"}],"tags":["europepmc-ingest"],"related":["myeloid-suppression-axis"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Nature reviews. Immunology","year":2019,"doi":"10.1038/s41577-019-0127-6","pmid":"30718830","authors":"DeNardo DG, Ruffell B","paperType":"review","findings":[],"whatItMeans":"One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-denardo-nat-rev-immunol/","neighbours":{"pathway":[{"id":"myeloid-suppression-axis","kind":"pathway","name":"Myeloid suppression: TAMs, MDSCs & don't-eat-me signals","route":"/pathways/myeloid-suppression-axis/"}]}}