{"entity":{"id":"paper-dreyer-xpert-bladder-dablaca-15-eur-urol-2025","kind":"paper","name":"Use of the Xpert Bladder Cancer Monitor Urinary Biomarker Test for Guiding Cystoscopy in High-grade Non-muscle-invasive Bladder Cancer: Results from the Randomized Controlled DaBlaCa-15 Trial","aka":[],"tldr":"A Danish randomised trial in which a urine RNA test was used to decide when people under bladder cancer follow-up needed a camera examination of the bladder.","summary":"1,029 cystoscopies were performed in the control arm and 445 in the intervention arm. The risk difference for high-grade recurrence was 0.08 per cent (95% CI minus 7.2 to 7.4), and two pTa high-grade recurrences were missed.","asOf":"2026-11-04","links":[{"label":"Dreyer et al., Eur Urol 2025","url":"https://doi.org/10.1016/j.eururo.2025.03.018"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/40280776/"}],"tags":[],"related":[],"cancers":["non-muscle-invasive-bladder-cancer"],"sections":["diagnostics"],"technologies":["liquid-rna-biopsy","urine-bladder-cancer-tests"],"targets":[],"drugs":["xpert-bladder-cancer-monitor"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"European Urology","year":2025,"doi":"10.1016/j.eururo.2025.03.018","pmid":"40280776","authors":"Dreyer T, Brandt S, Fabrin K, et al.","paperType":"rct","findings":["Cystoscopies 1,029 (control) against 445 (test-guided).","High-grade recurrence risk difference 0.08% (95% CI -7.2 to 7.4)."],"whatItMeans":"A urine RNA test cut camera examinations by more than half in this trial, with two missed recurrences.","caveats":["Wide confidence interval for recurrence."]},"route":"/key-papers/paper-dreyer-xpert-bladder-dablaca-15-eur-urol-2025/","neighbours":{"cancer":[{"id":"non-muscle-invasive-bladder-cancer","kind":"cancer","name":"Non-muscle-invasive bladder cancer","route":"/cancers/non-muscle-invasive-bladder-cancer/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"},{"id":"urine-bladder-cancer-tests","kind":"technology","name":"Urine tests for bladder cancer (cytology, FISH, RNA and methylation)","route":"/technologies/urine-bladder-cancer-tests/"}],"drug":[{"id":"xpert-bladder-cancer-monitor","kind":"drug","name":"Xpert Bladder Cancer Monitor","route":"/drugs/xpert-bladder-cancer-monitor/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}