{"entity":{"id":"paper-dxcover-spectroscopy-bjc-2023","kind":"paper","name":"A spectroscopic liquid biopsy for the earlier detection of multiple cancer types","aka":[],"tldr":"Dxcover shone infrared light through blood serum from 2,092 people and used machine learning to tell eight cancer types from no cancer.","summary":"Cameron and colleagues applied the Dxcover Cancer Liquid Biopsy, Fourier transform infrared spectroscopy with machine learning, to 2,092 patients across eight cancers. Areas under the curve against symptomatic non-cancer controls were brain 0.90, breast 0.76, colorectal 0.91, kidney 0.91, lung 0.91, ovarian 0.86, pancreatic 0.84 and prostate 0.86. Pooling all eight against asymptomatic non-cancer controls, the model detected 64% of stage I cancers at 99% specificity (overall sensitivity 57%); tuned for sensitivity it found 99% of stage I cancers at 59% specificity.","asOf":"2026-10-29","links":[{"label":"British Journal of Cancer 2023","url":"https://doi.org/10.1038/s41416-023-02423-7"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/37717120/"}],"tags":[],"related":[],"cancers":[],"sections":["early-detection"],"technologies":["mced"],"targets":[],"drugs":["dxcover-cancer-liquid-biopsy"],"companies":["dxcover"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["british-journal-of-cancer"],"dependsOn":[],"notes":[],"journal":"British Journal of Cancer","year":2023,"doi":"10.1038/s41416-023-02423-7","pmid":"37717120","authors":"Cameron JM, Sala A, Antoniou G, et al.","paperType":"translational","findings":["Eight cancer types, areas under the curve 0.76 to 0.91.","64% of stage I cancers at 99% specificity; overall sensitivity 57%."],"whatItMeans":"A cheap, fast signal with promising discovery-stage figures; it has not been tested in a screening population.","caveats":["Discovery study with known cancers.","Authors include Dxcover staff."],"changedPractice":false,"participants":2092},"route":"/key-papers/paper-dxcover-spectroscopy-bjc-2023/","neighbours":{"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"drug":[{"id":"dxcover-cancer-liquid-biopsy","kind":"drug","name":"Dxcover Cancer Liquid Biopsy","route":"/drugs/dxcover-cancer-liquid-biopsy/"}],"company":[{"id":"dxcover","kind":"company","name":"Dxcover","route":"/companies/dxcover/"}],"journal":[{"id":"british-journal-of-cancer","kind":"journal","name":"British Journal of Cancer","route":"/journals/british-journal-of-cancer/"}]}}